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What structure is formed by two sister chromatids being held together by a centromere?


A) chromosome
B) chromatin
C) histones
D) nucleosome
E) DNA

F) A) and B)
G) A) and C)

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Which lifestyle choice is responsible for 90% of the cases of lung cancer among men?


A) smoking
B) using tanning beds
C) excessive alcohol consumption
D) drug use
E) using smokeless tobacco

F) C) and D)
G) A) and D)

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The figure below shows a cell in the mitotic stage of The figure below shows a cell in the mitotic stage of   A)  anaphase. B)  interphase. C)  metaphase. D)  prophase. E)  telophase.


A) anaphase.
B) interphase.
C) metaphase.
D) prophase.
E) telophase.

F) A) and E)
G) A) and B)

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The spindle serves two roles in mitotic cell division. These are to separate the


A) sister chromatids and to elongate the cell.
B) non-sister chromatids and then the homologous chromosomes.
C) sister chromatids and then the non-sister chromatids.
D) sister chromatids and then form the cleavage furrow.
E) homologous chromosomes and then form the cleavage furrow.

F) A) and B)
G) B) and E)

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If cancer is discovered at an early stage, which treatment method is most often used?


A) surgery
B) radiation
C) chemotherapy
D) hormonal therapy
E) drug therapy

F) B) and E)
G) All of the above

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If a cell stops at the G1 checkpoint, this is most likely due to what problem?


A) There is DNA damage.
B) The DNA has not finished replicating.
C) The chromosomes are not aligned properly.
D) The cell is cancerous.
E) There is no problem. The cell normally stops at the G1 checkpoint.

F) A) and C)
G) B) and E)

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Embryonic cells and cancer cells are similar because


A) DNA polymerase is inactive.
B) telomerase is active.
C) telomerase is inactive.
D) RNA polymerase is inactive.
E) proto-oncogenes are inactive.

F) C) and E)
G) A) and C)

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Nuclear division is represented in the figure below by the letter Nuclear division is represented in the figure below by the letter   A)  a. B)  b. C)  c. D)  d. E)  e.


A) a.
B) b.
C) c.
D) d.
E) e.

F) B) and D)
G) None of the above

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When a portion of a chromosome breaks off and attaches to a different chromosome, this is called a


A) translocation.
B) telomerase.
C) apoptosis event.
D) suppressor event.
E) jumping gene.

F) None of the above
G) B) and C)

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A tumor suppressor gene undergoes a mutation that causes it to lose its normal function. What would be the most likely result of this mutation?


A) The cell cycle halts and reverses back to the G0 stage.
B) The cell loses contact inhibition even when it is not surrounded by other cells.
C) The cell cycle accelerates.
D) The cell no longer responds to signals that cause it to stop dividing or undergo apoptosis.
E) The cell stops dividing permanently and will never re-enter the cell cycle.

F) B) and E)
G) A) and D)

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The structures labeled "d" in the following figure are called The structures labeled  d  in the following figure are called   A)  centromeres. B)  centrioles. C)  sister chromatids. D)  spindles. E)  non-sister chromatids.


A) centromeres.
B) centrioles.
C) sister chromatids.
D) spindles.
E) non-sister chromatids.

F) B) and C)
G) A) and B)

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Some of the drugs used in chemotherapy work by


A) increasing telomeres.
B) preventing spindle formation.
C) producing kinases.
D) inhibiting cytokinesis.
E) causing cells to divide quickly.

F) B) and D)
G) C) and E)

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Angiogenesis contributes to carcinogenesis because it


A) allows tumor cells to spread to other parts of the body.
B) causes blood vessels to grow into the tumor.
C) allows tumor cells to invade underlying tissues.
D) causes additional mutations to occur in tumor cells.
E) causes apoptosis in tumor cells.

F) A) and C)
G) B) and E)

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Which of the following represents the phases of mitosis in their proper sequence?


A) prophase, metaphase, anaphase, telophase
B) interphase, prophase, metaphase, telophase
C) anaphase, interphase, prophase, metaphase, telophase
D) prophase, metaphase, anaphase, telophase, cytokinesis
E) metaphase, interphase, cytokinesis, anaphase, telophase

F) A) and E)
G) B) and C)

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When during the cell cycle are chromosomes visible?


A) only during interphase
B) only when they are being copied
C) during mitosis
D) only during the G1 phase
E) Chromosomes are always visible.

F) B) and E)
G) A) and B)

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A cell is inhibited during the S phase of its cycle. It will not reproduce due to lack of


A) ATP availability.
B) centriole migration.
C) centromere formation.
D) DNA synthesis.
E) plasma membrane structure.

F) B) and C)
G) A) and B)

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Which items in the following pairs are correctly matched?


A) G1 phase - DNA replication
B) G2 phase - preparation for meiosis
C) S phase - DNA replication
D) M phase - cell growth
E) G0 phases - cell growth

F) A) and E)
G) A) and D)

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Proto-oncogenes function by preventing cells from dividing uncontrollably.

A) True
B) False

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Inheritance of mutant forms of some genes may lead to a predisposition to develop cancer. Which of the genes listed below has not been linked to hereditary forms of cancer?


A) BRCA1
B) RB
C) RET
D) RAS
E) DScam

F) None of the above
G) B) and E)

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Cytokinesis usually, but not always, follows mitosis. If a cell undergoes mitosis and not cytokinesis, this would result in


A) a cell with a single large nucleus.
B) a cell with two or more nuclei.
C) cells with abnormally small nuclei.
D) feedback responses that prevent mitosis.
E) death of the cell line.

F) A) and B)
G) A) and E)

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