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If a chromosome contains a mutation such that it cannot bind to the kinetochore complex, what would be the consequence?


A) That chromosome would not be able to be replicated.
B) That chromosome would not be able to condense.
C) That chromosome would not be able to bind to the mitotic spindle.
D) That chromosome would not be able to interact with histone proteins.

E) C) and D)
F) B) and C)

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If there are 32 sister chromatids in a normal somatic cell, how many chromosomes are there?


A) 8
B) 16
C) 32
D) 64

E) B) and C)
F) B) and D)

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What is one of the roles of the APC/C during anaphase?


A) To directly target the mitotic cyclins for destruction.
B) To directly target cohesin for destruction.
C) To directly target separase for destruction.
D) To directly target microtubules for destruction.

E) All of the above
F) C) and D)

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In later chapters, you will learn more about the regulation of gene expression.One way to regulate gene expression is to make changes to the histone proteins to alter how tightly the DNA is coiled and wrapped.The more tightly coiled and wrapped a particular region of DNA is, the less likely it is that the genes in that region will be expressed.Bearing this in mind, how tightly do you think regions of heterochromatin are compacted?


A) Very tightly
B) Moderately
C) Loosely
D) Not at all

E) B) and C)
F) A) and C)

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What stage of mitosis is essentially the reverse of prophase?


A) Anaphase
B) Prometaphase
C) Metaphase
D) Telophase

E) A) and C)
F) A) and B)

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The physical distribution of cytoplasmic material into the two daughter cells in plant cells is referred to as:


A) The gap phase
B) Cytokinesis
C) Binary fission
D) Interphase

E) C) and D)
F) None of the above

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The point of constriction on chromosomes that contains certain repeated DNA sequences that bind specific proteins is called:


A) The kinetochore
B) The centromere
C) The cohesin complex
D) The centriole

E) A) and D)
F) All of the above

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This stage of mitosis is characterized by the disassembly of spindle apparatus, the reestablishment of the nuclear membrane, and the decondensation of the chromosomes:


A) Prometaphase
B) Telophase
C) Anaphase
D) Metaphase

E) A) and B)
F) A) and C)

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The number of chromosomes in diploid eukaryotic cellsrev: 10_20_2014_QC_57039


A) is 46.
B) can be predicted by the size of the organism.
C) changes as each organism grows and ages.
D) varies considerably from 2 to over 1000 in different species.

E) All of the above
F) A) and D)

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These structures are held together by cohesin:


A) Nucleosomes
B) Sister chromatids
C) Homologous chromosomes
D) Solenoids

E) C) and D)
F) A) and D)

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Consider the cell cycle of a human cell.During G2, what is the state of the homologous chromosomes?


A) The homologous chromosomes are lined up on the equator of the cell.
B) The homologous chromosomes have all been copied through DNA replication and are beginning to condense.
C) The homologous chromosomes have been pulled to their respective poles by the spindle apparatus.
D) The homologous chromosomes have not been replicated yet.

E) A) and B)
F) A) and C)

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During this stage of mitosis, the nuclear envelope begins to break down and the spindle begins to form.


A) Anaphase
B) Metaphase
C) Prophase
D) Telophase

E) B) and C)
F) A) and C)

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Plant cells typically achieve cytokinesis by:


A) binary fission.
B) forming a cell plate across the middle of the cell.
C) forming a cleavage furrow that pinches the cell into two.
D) chromosome condensation.

E) A) and D)
F) All of the above

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The progress of the eukaryotic cell cycle is regulated primarily by what proteins?


A) Cyclins
B) Histone proteins
C) Condensins
D) FtsZ

E) B) and D)
F) A) and B)

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The drug Taxol, or Paclitaxel, is used to treat patients with a variety of cancers, including breast, lung and ovarian cancers.The drug works by stabilizing microtubules, and preventing their disassembly.The goal of the drug is to prevent dividing cells from being able to complete mitosis.As a result, cancerous cells can no longer divide.In a cell treated with Taxol, at what stage of mitosis will the cells arrest?


A) Prior to metaphase
B) Anaphase
C) Telophase
D) Cytokinesis

E) All of the above
F) C) and D)

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If a cell was capable of bypassing metaphase and going directly from prometaphase to anaphase, what is the most likely consequence of this?


A) The resulting daughter cells would not have a nuclear envelope.
B) The resulting daughter cells would have significantly different quantities of cytoplasmic materials.
C) The resulting daughter cells would have different numbers of chromosomes.
D) The resulting daughter cells would be completely normal.

E) B) and D)
F) All of the above

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At what checkpoint(s) does the cell arrest in response to DNA damage?


A) G1/S
B) G2/M
C) spindle
D) G1/S and G2/M

E) B) and D)
F) B) and C)

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What is separase?


A) A protein that marks a protein called securin for destruction.
B) A protein that is part of the cohesin complex.
C) A protein that destroys cohesin through its protease activity.
D) A protein that targets the mitotic cyclin for degradation.

E) All of the above
F) None of the above

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If a cell has 32 chromosomes prior to S and undergoes mitosis followed by cytokinesis, each new daughter cell will have how many chromosomes?


A) 64
B) 32
C) 16
D) 8

E) A) and C)
F) B) and C)

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Why is it so important that all of the chromosomes align on the metaphase plate during metaphase?


A) This is the only place in the cell where the cyclins and Cdks are located.
B) If they cannot, it suggests that they aren't properly attached to the spindle microtubules, and thus won't separate properly during anaphase.
C) This is the location where the chromosomes can become attached to the spindle microtubules.
D) This allows asters to form.

E) A) and B)
F) B) and D)

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