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Which three classes of macromolecules are encoded by mtDNA?

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proteins, ...

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The genes for light eyes (lt; light) and straw bristles (stw; straw) are tightly linked on chromosome 2 in Drosophila melanogaster. The Malpighian tubes of lt larvae and adults are maternally affected in that Malpighian tubes of lt/lt organisms, whose mothers were lt+/lt and have more yellow pigment than those from lt/lt mothers. There is no maternal effect associated with the straw locus. Give the phenotypes of the offspring from the following crosses. Female Male Cross #1: lt stw/lt stw lt+stw+/lt stw Cross #2: lt+ stw/lt stw lt stw+/lt stw Cross #3: lt+ stw+/lt stw lt stw/lt stw

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Cross #1: 1/2 light Malpighian...

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Researchers in the late 1950s isolated multiple antibiotic-resistant strains of the bacterium Shigella, which causes dysentery. Such resistance was caused by nonchromosomal R factors that originated in E. coli. Which of the following forms of extrachromosomal heredity-maternal effect, organelle heredity, infectious heredity-would you consider most closely related to the transfer bacterial antibiotic-resistant strains?

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Forms of inheritance that do not follow typical Mendelian patterns and that appear to be more influenced by the parent contributing the most cytoplasm to the embryo are grouped under the general heading of ________.


A) sex-linked inheritance
B) neo-Mendelian inheritance
C) extrachromosomal inheritance
D) suppressive inheritance
E) dominance and/or recessiveness

F) A) and B)
G) D) and E)

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C

Direction of shell coiling in the snail Lymnaea peregra is conditioned by a form of extrachromosomal inheritance known as ________.


A) sex-linked inheritance
B) heteroplasmy
C) maternal effect
D) independent assortment
E) epistasis

F) D) and E)
G) B) and E)

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Through the study of mitochondrial disorders, scientists have suggested a link between the decline of mitochondrial function and aging. What process appears to be involved in this suspected phenomenon?


A) accumulation of sporadic mutations in the nuclear genome
B) decline of mutations in the nuclear genome
C) accumulation of mutations in the mtDNA
D) recombination of mtDNA and nuclear DNA
E) recombination among mtDNAs of different mitochondria

F) B) and D)
G) All of the above

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Direction of shell coiling in Lymnaea peregra is influenced by a maternal effect.

A) True
B) False

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In what way do chloroplast mutations influence phenotype?

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Chloroplast mutations affect t...

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An example of organelle heredity involves pigmentation in Mirabilis jalapa.

A) True
B) False

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True

Describe the molecular and transmission characteristics of Leber's hereditary optic neuropathy (LHON).

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maternal inheritance...

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List three organisms that provide examples of organelle heredity.

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Homo sapiens, Mirabi...

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Mitochondrial mutations are passed equally to offspring by both males and females.

A) True
B) False

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It appears as if the direction of shell coiling in Lymnaea peregra is influenced by the orientation of the first cleavage division.

A) True
B) False

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Name two human disorders that appear to be transmitted extrachromosomally.

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myoclonic epilepsy a...

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Why is variegation in four o'clock plants determined by the phenotype of the ovule source?

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The chloroplasts determine the...

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In what way do segregational petite mutations differ from neutral petites?

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Segregational petites follow M...

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What is the meaning of the term endosymbiotic theory?

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The endosymbiotic theory states that mitochondria and chloroplasts arose independently about 2 billion years ago from free-living proteobacteria.

The maternal effect in Lymnaea is such that the genotype of the egg determines the direction of shell coiling regardless of the genotype of the offspring. Apparently, the cause of this spectacular maternal effect results from ________.


A) orientation of the spindle apparatus in early cleavage
B) genophores present in the egg cytoplasm
C) the F factor exerting its influence on the centrosome
D) colicins "poisoning" one of the cleavage centers
E) allelic substitution as demonstrated from RNA injection experiments

F) C) and D)
G) A) and D)

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One explanation for organelle inheritance is that ________.


A) mitochondria and chloroplasts lack DNA and are therefore dependent on the maternal cytoplasmic contributions
B) mitochondria and chloroplasts have DNA that is subject to mutation
C) organelles such as mitochondria are always wild type
D) chloroplasts, for example, are completely dependent on the nuclear genome for components
E) None of the answers listed are correct.

F) A) and E)
G) A) and D)

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What is the expression pattern of dominant-negative mutations in petite strains of yeast?


A) Expression of wild-type mitochondria is enhanced.
B) Expression of mutant mitochondria resembles expression of wild-type mitochondria.
C) Mitochondria show enhanced capacity of oxidative phosphorylation.
D) The function of wild-type mitochondria is suppressed.
E) Mitochondrial membranes become hyperpolarized.

F) A) and B)
G) A) and C)

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